Structural Genomics: Correlation Blocks, Population Structure, and Genome Architecture
نویسندگان
چکیده
منابع مشابه
Structural Genomics: Correlation Blocks, Population Structure, and Genome Architecture
An integration of the pattern of genome-wide inter-site associations with evolutionary forces is important for gaining insights into the genomic evolution in natural or artificial populations. Here, we assess the inter-site correlation blocks and their distributions along chromosomes. A correlation block is broadly termed as the DNA segment within which strong correlations exist between genetic...
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Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure prediction methods will provide valuable info...
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20.3 Global Patterns of Human Population Structure ....... 595 20.3.1 The Apportionment of Human Diversity ..................................................... 595 20.3.2 The History and Geography of Human Genes ......................................... 596 20.3.3 Genetic Structure of Human Populations ... 598 20.3.4 A Haplotype Map of the Human Genome ............................................
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The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB, http://kb.psi-structuralgenomics.org) has been created to turn the products of the PSI structural genomics effort into knowledge that can be used by the biological research community to understand living systems and disease. This resource provides central access to structures in the Protein Data Bank (PDB), along with...
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The success of structural genomics initiatives requires the development and application of tools for structure analysis, prediction, and annotation. In this paper we review recent developments in these areas; specifically structure alignment, the detection of remote homologs and analogs, homology modeling and the use of structures to predict function. We also discuss various rationales for stru...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2011
ISSN: 1389-2029
DOI: 10.2174/138920211794520141